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Cardiovascular Agents

Lipistad 10/ Lipistad 20

Pack size:

Lipistad 10: Box of 30 tablets/ 50 tablets

Lipistad 20: Box of 30 tablets

 

Composition:

Each Lipistad 10 film-coated tablet contains Atorvastatin 10 mg

Each Lipistad 20 film-coated tablet contains Atorvastatin 20 mg


Shelf-life:  

Lipistad 10: 36 months from the date of manufacturing.

Lipistad 20: 24 months from the date of manufacturing.

Store in a well-closed container, in a dry place. Protect from light. Do not store above 30oC.

  • Indications and Dosage & Administration
  • Contraindications
  • Adverse reactions
  • Precautions

  • The treatment of hyperlipidaemias, including hypercholesterolaemias and combined (mixed) hyperlipidaemia (type IIa or IIb hyperlipoproteinaemias), hypertriglyceridaemia (type IV), and dysbetalipoproteinaemia (type III).
  • Adjunctive therapy in patients with homozygous familial hypercholesterolaemia.

Lipistad is administered orally once daily, without regard to meals.

The patient should be placed on a standard cholesterol-lowering diet before receiving atorvastatin and should continue on this diet during treatment with the drug.

The drug should be initiated with a lowest effective dose, thereafter dosage of atorvastatin may be increased at intervals of no less than 4 weeks, if necessary.

The management of primary hypercholesterolemia (heterozygous familial or non-familial) and mixed dyslipidemia in adults: commence with 10 or 20 mg once daily or 40 mg daily (in patients requiring reductions in LDL-cholesterol of more than 45% to achieve their goal). The usual maintenance dosage is 10 - 80 mg once daily.

Treatment of heterozygous familial hypercholesterolemia in boys and postmenarchal girls 10 years of age or older: 10 mg once daily; the maximum dose of 20 mg daily.

The management of homozygous familial hypercholesterolemia: 10 - 80 mg once daily.

For patients taking drugs that interact with atorvastatin:

Ciclosporin: Maximum dose 10 mg once daily.

Clarithromycin: Initial dose 10 mg once daily and maximum dose 20 mg once daily.

Itraconazole: Initial dose 10 mg once daily and maximum dose 40 mg once daily.

Lopinavir plus ritonavir: Use with caution and use with the lowest atorvastatin dose necessary.

Amiodarone, Darunavir plus ritonavir, fosamprenavir, fosamprenavir plus ritonavir, saquinavir plus ritonavir: Do not exceed 20 mg atorvastatin daily.

Nelfinavir: Do not exceed 40 mg atorvastatin daily.

Tipranavir plus ritonavir, telaprevir: Avoid atorvastatin.

 

Or as prescribed by physicians.

  • Known hypersensitivity to any of the active substance or excipients.
  • Patients with active liver disease or unexplained, persistent increases in serum aminotransferase concentrations.
  • Pregnancy and lactation.

Adverse reactions have usually been mild and transient. The most frequent adverse events thought to be related to atorvastatin were constipation, flatulence, dyspepsia, and abdominal pain.

Use with caution in patients who consume substantial amounts of alcohol and/or have a history of liver disease; renal impairment, hypothyroidism, personal or familial history of hereditary muscular disorders, previous history of muscular toxicity with a statin or fibrate, previous history of liver disease and/or where substantial quantities of alcohol are consumed, in elderly (age > 70 years) with the presence of other predisposing factors for rhabdomyolysis: If CK > 5 times upper limit of normal at baseline, treatment should not be started. If muscular pain, weakness or cramps occur, CK levels should be measured.

Atorvastatin therapy should be temporarily withheld or discontinued in any patients with an acute, serious condition suggestive of a myopathy or having a risk factor predisposing to the development of renal failure secondary to rhabdomyolysis.

Patients should be aware of how they react to drug before driving or operating machinery.

Contact us

FACTORY 1: K63/1 Nguyen Thi Soc St., Xuan Thoi Dong, Hoc Mon, HCMC
Tel: +84 28 3718 2141 - Fax: +84 28 3718 2140

FACTORY 2: 40 Tu Do Avenue, VietNam-Singapore Industrial Park, Binh Duong
Tel: +84 274 376 7470 - Fax: +84 274 376 7469
Email : stada@stada.com.vn
Website: www.stada.com.vn



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